Journal: Leukemia

Article Title: Synergizing hypomethylating agents with off-the-shelf CD70-targeted chimeric antigen receptor-engineered natural killer T cells for the treatment of acute myeloid leukemia

doi: 10.1038/s41375-026-02930-5

Figure Lengend Snippet: A Diagram showing the generation of cord blood HSPC-derived allogeneic IL-15-enhanced CAR70-NKT ( Allo CAR70-NKT) cells, as well as healthy donor PBMC-derived IL-15-enhanced CAR70-NKT ( PBMC CAR70-NKT) cells. B FACS plots showing the generation of Allo CAR70-NKT cells, their CD4/CD8 co-receptor profiles over the 6-week culture, and CAR70 expression on week 6 cells detected with an anti-human CD27 antibody. C FACS plots showing the generation of PBMC CAR70-NKT cells, their CD4/CD8 co-receptor profiles over the 2-week culture, and CAR70 expression on week 2 cells detected with an anti-human CD27 antibody. Purity ( D ), CAR expression level ( E ), and yield ( F ) of Allo CAR70-NKT and PBMC CAR70-NKT cells ( n = 5; n indicated different CB or PBMC donors). G Table showing the expected yield and dose of Allo CAR70-NKT and PBMC CAR70-NKT cells when delivered to cancer patients. H ELISA measurements of human IL-15 production by Allo CAR70-NKT and PBMC CAR70-NKT cells stimulated with αGC and cultured in vitro for 5 days ( n = 5). Representative of 3 experiments. Data are presented as the mean ± SEM. ns, not significant; * p < 0.05, ** p < 0.01, **** p < 0.0001, by Student’s t test ( D , E , and H ). HSPC hematopoietic stem and progenitor cell, NKT invariant natural killer T, CAR70 CD70-targeting chimeric antigen receptor, CB cord blood, PBMC peripheral blood mononuclear cell.

Article Snippet: Healthy donor PBMCs were obtained from the UCLA/CFAR Virology Core Laboratory and HemaCare under informed consent and in compliance with federal and state regulations; no identifying information was provided.

Techniques: Derivative Assay, Expressing, Enzyme-linked Immunosorbent Assay, Cell Culture, In Vitro

Journal: bioRxiv

Article Title: scDynOmics: An Optimized Transformer Model for Representation Learning from Single-Cell Multiomics

doi: 10.64898/2026.02.28.708160

Figure Lengend Snippet: a , Schematic of the experimental workflow: pretraining is conducted on a specialized, limited corpus of human scMultiomic immune cell profiles, followed by fine-tuning on the monomodal Zheng68k scRNA-seq peripheral blood mononuclear cell (PBMC) dataset. b , Comparison of classification accuracy across 10-fold cross-validation. scDynOmics configurations reach comparable performance with the theoretical linear baseline (Logistic Regression) while outperforming other foundation models. c , Comparison of weighted F1-scores, highlighting the model’s robustness in classifying imbalanced cell types compared to baselines.

Article Snippet: The raw human scMultiomic immune cell datasets were obtained from the 10x Genomics Datasets portal: Lymph Node with B Cell Lymphoma, Human PBMCs via Chromium X, Human PBMCs via Chromium Controller, Healthy Donor PBMCs (3k), Healthy Donor PBMCs (10k) .

Techniques: Comparison, Biomarker Discovery